Enhanced Anti-Obesity Activities of Red Mold Dioscorea When Fermented Using Deep Ocean Water as the Culture Water

Marine Drugs

Li-Chun Wang¹  Tzu-Ying Lung³  Yi-Hsin Kung³  Jyh-Jye Wang²  Tsung-Yu Tsai⁵  Bai-Luh Wei³  Tzu-Ming Pan⁴ 

[1] Continuing Education School, National Taitung Junior College, Taitung 95045, Taiwan; E-Mail:;Department of Nutrition and Health Science, Fooyin University, Kaohsiung 83102, Taiwan; E-Mail:;Department of Life Science, National Taitung University, 684, Sec. 1, Chunghua Rd., Taitung 95092, Taiwan; E-Mails:;Department of Biochemical Science and Technology, National Taiwan University, Taipei 10617, Taiwan; E-Mail:;Department of Food Science, Fu Jen Catholic University, New Taipei 24205, Taiwan; E-Mail:

关键词: deep ocean water;    obesity;    Monascus;    monascin;    ankaflavin;   

DOI  :  10.3390/md11103902

来源: mdpi

【 摘 要 】

Deep ocean water (DOW) has, in previous studies, been found to be a novel anti-obesity drink and useful in raising Monascus-produced monascin and ankaflavin levels. This may resolve the limited anti-obesity ability of red mold dioscorea (RMD) known as the Monascus purpureus-fermented Disocorea batatas. This study aims to compare the anti-obesity effect of DOW-cultured RMD (DOW-RMD) and ultra-pure water-cultured RMD (UPW-RMD) in rats fed on a high fat diet. Moreover, the effect of ions composition of DOW and DOW-influenced functional metabolites change of RMD on the differentiation and lipogenesis regulation were investigated using 3T3-L1 pre-adipocytes. In the animal test, compared to UPW-RMD, DOW-RMD possessed better ability to inhibit increases in weight gain, and better feed efficiency, body-fat pad and cross-sectional area of adipocytes. In the cell test, the anti-obesity abilities of DOW-RMD in inhibiting PPARγ and C/EBPα expression in differentiation and lipoprotein lipase activity in lipogenesis were contributed to by the DOW-increased monascin and ankaflavin levels and the ions of DOW, respectively.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.