Molecules | |
G-Quadruplex Structures in the Human Genome as Novel Therapeutic Targets | |
Joanna Bidzinska1  Graziella Cimino-Reale1  Nadia Zaffaroni2  | |
[1]Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Via G. Amadeo 42, Milano 20133, Italy | |
关键词: G-quadruplex; oncogene; small molecules; telomeres; | |
DOI : 10.3390/molecules181012368 | |
来源: mdpi | |
【 摘 要 】
G-quadruplexes are secondary structures that may form within guanine-rich nucleic acid sequences. Telomeres have received much attention in this regard since they can fold into several distinct intramolecular G-quadruplexes, leading to the rational design and development of G-quadruplex‑stabilizing molecules. These ligands were shown to selectively exert an antiproliferative and chemosensitizing activity in
【 授权许可】
CC BY
© 2013 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO202003190032549ZK.pdf | 1219KB | download |