Serial Changes of Serum Growth Factor Levels and Liver Regeneration after Partial Hepatectomy in Healthy Humans

International Journal of Molecular Sciences

Kazuyuki Matsumoto²  Yasuhiro Miyake²  Yuzo Umeda¹  Hiroshi Matsushita²  Hiroaki Matsuda¹  Akinobu Takaki²  Hiroshi Sadamori¹  Kazuhiro Nouso²  Takahito Yagi¹  Toshiyoshi Fujiwara¹ 

[1] Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2-5-1, Shikata-cho, Kita-ku, Okayama 700-8558, Japan; E-Mails:;Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2-5-1, Shikata-cho, Kita-ku, Okayama 700-8558, Japan; E-Mails:

关键词: hepatectomy;    hepatocyte growth factor;    human;    leptin;    liver regeneration;    macrophage colony-stimulating factor;   

DOI  :  10.3390/ijms141020877

来源: mdpi

【 摘 要 】

This study aimed to investigate the associations of the serial changes of serum levels of various growth factors with liver regeneration after hepatectomy in healthy liver donors. Sixteen healthy liver donors who underwent conventional liver resection were included. Serum levels of various growth factors before hepatectomy and on postoperative day (POD) 1, 3, 5 and 7 were measured. Liver volume data calculated by multi-detector computed tomography using workstation. The ratio of remnant liver volume on POD 0 to liver volume before the operation was 51% ± 20%. The ratio of liver volume on POD 14 to liver volume on POD 0 were inversely correlated with remnant liver volume on POD 0 (r = −0.91). The ratio of liver volume on POD 14 to liver volume on POD 0 were significantly correlated with serum hepatocyte growth factor (HGF) levels on POD 1 (r = 0.54), serum leptin levels on POD 1 (r = 0.54), and serum macrophage colony-stimulating factor (M-CSF) levels on POD 5 (r = 0.76) and POD 7 (r = 0.80). These results suggest that early-phase elevation of serum levels of HGF, leptin and M-CSF may be associated with the acceleration of liver regeneration after hepatectomy in humans.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland