Appraisal of Antiophidic Potential of Marine Sponges against Bothrops jararaca and Lachesis muta Venom

Toxins

Camila Nunes Faioli²  Thaisa Francielle Souza Domingos²  Eduardo Coriolano de Oliveira²  Elฝio Flores Sanchez¹  Suzi Ribeiro³  Guilherme Muricy³ 

[1] Ezequiel Dias Foundation, Belo Horizonte 30510-010, MG, Brazil; E-Mail:;Department of Molecular and Cellular Biology, Institute of Biology, Federal Fluminense University, Niteroi 24020-141, RJ, Brazil; E-Mails:;Department of Invertebrates, Federal University of Rio de Janeiro, National Museum 20940-040, RJ, Brazil; E-Mails:

关键词: Brazilian sponges;    Bothrops jararaca;    Lachesis muta;    snake venom;    neutralization;   

DOI  :  10.3390/toxins5101799

来源: mdpi

【 摘 要 】

Snakebites are a health problem in many countries due to the high incidence of such accidents. Antivenom treatment has regularly been used for more than a century, however, this does not neutralize tissue damage and may even increase the severity and morbidity of accidents. Thus, it has been relevant to search for new strategies to improve antiserum therapy, and a variety of molecules from natural sources with antiophidian properties have been reported. In this paper, we analyzed the ability of ten extracts from marine sponges (Amphimedon viridis, Aplysina fulva, Chondrosia collectrix, Desmapsamma anchorata, Dysidea etheria, Hymeniacidon heliophila, Mycale angulosa, Petromica citrina, Polymastia janeirensis, and Tedania ignis) to inhibit the effects caused by Bothrops jararaca and Lachesis muta venom. All sponge extracts inhibited proteolysis and hemolysis induced by both snake venoms, except H. heliophila, which failed to inhibit any biological activity. P. citrina inhibited lethality, hemorrhage, plasma clotting, and hemolysis induced by B. jararaca or L. muta. Moreover, other sponges inhibited hemorrhage induced only by B. jararaca. We conclude that Brazilian sponges may be a useful aid in the treatment of snakebites caused by L. muta and B. jararaca and therefore have potential for the discovery of molecules with antiophidian properties.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.