Synthesis and Protective Effect of New Ligustrazine-Benzoic Acid Derivatives against CoCl2-Induced Neurotoxicity in Differentiated PC12 Cells

Molecules

Penglong Wang²  Honggui Zhang²  Fuhao Chu²  Xin Xu²  Jinxuan Lin¹  Chunxiao Chen¹  Guoliang Li²  Yatao Cheng²  Lin Wang²  Qiang Li²  Yuzhong Zhang¹ 

[1] Department of Pathology, Beijing University of Chinese Medicine, Beijing 100102, China; E-Mails:;School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China; E-Mails:

关键词: ligustrazine;    neuroprotective effect;    cobalt chloride;    PC12 cell;    HE staining;   

DOI  :  10.3390/molecules181013027

来源: mdpi

【 摘 要 】

A series of novel ligustrazine-benzoic acid derivatives were synthesized and evaluated for their protective effect against cobalt chloride-induced neurotoxicity in differentiated PC12 cells. Combining hematoxylin and eosin staining, we found compound that (3,5,6-trimethylpyrazin-2-yl)methyl 3-methoxy-4-[(3,5,6-trimethylpyrazin-2-yl)methoxy]benzoate (4a) displayed promising protective effect on the proliferation of the injured PC12 cells (EC₅₀ = 4.249 µM). Structure-activity relationships are briefly discussed.

【 授权许可】

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