Red Algal Bromophenols as Glucose 6-Phosphate Dehydrogenase Inhibitors

Marine Drugs

Daisuke Mikami²  Hideyuki Kurihara²  Sang Moo Kim¹ 

[1] Department of Marine Food Science and Technology, Gangneung-Wonju National University, Gangneung, Gangwon-do 210-702, Korea; E-Mail:;Faculty and Graduate School of Fisheries Sciences, Hokkaido University, Minato, Hakodate, Hokkaido 041-8611, Japan; E-Mails:

关键词: bromophenol;    Rhodomelaceae;    pentose phosphate pathway (PPP);    glucose 6-phosphate dehydrogenase;    inhibition;   

DOI  :  10.3390/md11104050

来源: mdpi

【 摘 要 】

Five bromophenols isolated from three Rhodomelaceae algae (Laurencia nipponica, Polysiphonia morrowii, Odonthalia corymbifera) showed inhibitory effects against glucose 6-phosphate dehydrogenase (G6PD). Among them, the symmetric bromophenol dimer (5) showed the highest inhibitory activity against G6PD.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.