Effect of Urinary Bisphenol A on Androgenic Hormones and Insulin Resistance in Preadolescent Girls: A Pilot Study from the Ewha Birth & Growth Cohort

International Journal of Environmental Research and Public Health

Hye Ah Lee⁴  Young Ju Kim⁵  Hwayoung Lee²  Hye Sun Gwak³  Eun Ae Park¹  Su Jin Cho¹  Hae Soon Kim¹  Eun Hee Ha⁴ 

[1] Department of Pediatrics, School of Medicine, Ewha Womans University, Seoul 158-710, Korea; E-Mails:;Department of Anatomy, School of Medicine, Ewha Womans University, Seoul 158-710, Korea; E-Mail:;Colleage of Pharmacy, Ewha Womans University, Seoul 120-750, Korea; E-Mail:;Department of Preventive Medicine, School of Medicine, Ewha Womans University, Seoul 158-710, Korea; E-Mails:;Department of Obstetrics and Gynecology, School of Medicine, Ewha Womans University, Seoul 158-710, Korea; E-Mail:

关键词: androgenic hormones;    bisphenol A;    child health;    endocrine disruptor chemicals;    insulin resistance;   

DOI  :  10.3390/ijerph10115737

来源: mdpi

【 摘 要 】

To assess the effect of urinary bisphenol A (BPA) on repeated measurements of androgenic hormones and metabolic indices, we used multivariate analysis of variance (MANOVA) adjusted for potential confounders at baseline. During July to August 2011, 80 preadolescent girls enrolled in the Ewha Birth & Growth Cohort study participated in a follow-up study and then forty-eight of them (60.0%) came back one year later. Baseline levels of estradiol and androstenedione were higher in the BPA group than in the non-BPA group. One year later, girls in the high BPA exposure group showed higher levels of androstenedione, testosterone, estradiol, and insulin, and homeostasis model assessment of insulin resistance (HOMA-IR) index, than those in the other groups (p < 0.05). In MANOVA, estradiol and androstenedione showed significant differences among groups, while dehydroepiandrosterone, insulin, and HOMA-IR showed marginally significant differences. Exposure to BPA may affect endocrine metabolism in preadolescents. However, further investigation is required to elucidate the mechanisms linking BPA with regulation of androgenic hormones.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.