Combination of Fenretinide and Selenite Inhibits Proliferation and Induces Apoptosis in Ovarian Cancer Cells

International Journal of Molecular Sciences

Jie Liu¹  Jia Li¹  Jian-Fang Zhang¹ 

[1] Department of Obstetrics and Gynecology, Xijing Hospital, the Fourth Military Medical University, Xi’an 710032, China;

关键词: ovarian cancers cell;    fenretinide;    selenite;    combination;    anti-tumor effect;   

DOI  :  10.3390/ijms141121790

来源: mdpi

【 摘 要 】

The combination of fenretinide and selenite on ovarian cancer cells was investigated to assess its effects on proliferation and ability to induce apoptosis. Our results showed that fenretinide and selenite in combination significantly suppress the proliferation of ovarian cancer cells and induced apoptosis (including reactive oxygen species generation, and the loss of mitochondrial membrane potential) compared with either drug used alone. The caspase3/9-dependent pathway was triggered significantly in combination treatment, and moreover, the AMPK pathway also mediated the apoptosis induction in fenretinide and selenite combination. Fenretinide and selenite combination treatment was demonstrated to suppress tumor growth in vivo, this drug combination has been thus found to have an enhanced anti-tumor effect on ovarian cancers cells.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland