Synthesis of 3,4-Dibenzyltetrahydrofuran Lignans (9,9′-Epoxylignanes)

Molecules

Monika Pohjoispää¹ 

[1] id="af1-molecules-18-13124">Laboratory of Organic Chemistry, Department of Chemistry, P.O. Box 55, FIN-00014, University of Helsinki, Helsinki, 00560, Finla

关键词: lignan;    trans-3;    4-dibenzyltetrahydrofuran;    tetrahydrofuran;    9;    9'-epoxylignane;    synthesis;   

DOI  :  10.3390/molecules181113124

来源: mdpi

【 摘 要 】

Different strategies for the racemic or enantiospecific total syntheses of plant and mammalian 3,4-dibenzyltetrahydrofuran lignans are reviewed and compared. The multi-step approaches have various key step strategies: Diels–Alder reactions, Stobbe condensations, Michael additions, alkylations, nitrile oxide cycloadditions, radical cyclisations, dianion and oxidative couplings.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.