Polyethylene Glycol (PEG-400): An Efficient and Recyclable Reaction Medium for the Synthesis of Pyrazolo[3,4-b]pyridin-6(7H)-one Derivatives

Molecules

Xiaoxing Zhong²  Guolan Dou¹ 

[1] id="af1-molecules-18-13139">School of Safety Engineering, China University of Mining &Technology, Xuzhou 221116, Jiangsu, Chi

关键词: pyrazolo[3;    4-b]pyridine-6(7H)-one;    recyclable polyethylene glycol;    aqueous media;    synthesis;   

DOI  :  10.3390/molecules181113139

来源: mdpi

【 摘 要 】

A mild and efficient synthesis of pyrazolo[3,4-b]pyridine-6(7H)-one derivatives via a three-component reaction of an aldehyde, Meldrum’s acid and 3-methyl-1H-pyrazol-5-amine using recyclable polyethylene glycol (PEG)-400 as a reaction medium is described. This method has the advantages of accessible starting materials, good yields, mild reaction conditions and begin environmentally friendly.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.