One Lignanoid Compound and Four Triterpenoid Compounds with Anti-Inflammatory Activity from the Leaves of Elaeagnus oldhamii Maxim

Molecules

Chi-Ren Liao³  Yu-Ling Ho²  Guan-Jhong Huang³  Chang Syun Yang³  Che-Yi Chao¹  Yuan-Shiun Chang³ 

[1] Health and Nutrition Biotechnology Department, Asia University, Taichung 41354, Taiwan;Nursing Department, Hung kuang University, Taichung 43302, Taiwan;School of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Pharmacy, China Medical University, Taichung 40402, Taiwan

关键词: traditional herbal medicine;    Elaeagnus oldhamii Maxim.;    lignanoid;    triterpenoid;    anti-inflammation;   

DOI  :  10.3390/molecules181113218

来源: mdpi

【 摘 要 】

One lignanoid compound, isoamericanol B (1), along with four triterpenoid compounds—cis-3-O-p-hydroxycinnamoyloleanolic acid (2), trans-3-O-p-hydroxy cinnamoyloleanolic acid (3), cis-3-O-p-hydroxycinnamoylursolic acid (4), trans-3-O-p-hydroxycinnamoylursolic acid (5) have been isolated for the first time from the leaves of Elaeagnus oldhamii Maxim. Compounds 1–4 significantly inhibited the expression of NO (nitric oxide) produced in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. The IC50 value for inhibition of nitrite production of compound 1 was about 10.3 ± 0.4 μg/mL. In the cell viability test, however, among compounds 1–4compound 1 did not significantly change cell viability. Therefore, in this study compound 1 possessed anti-inflammatory effects. The result suggests compound 1 as a potential lead compound for the treatment of inflammatory diseases.

【 授权许可】

CC BY   
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