Envelope Glycoprotein Trimers as HIV-1 Vaccine Immunogens

Vaccines

关键词: HIV-1;    vaccine;    neutralizing antibodies;    envelope glycoproteins;    trimer;   

DOI  :  10.3390/vaccines1040497

来源: mdpi

【 摘 要 】

The HIV-1 envelope glycoprotein spike is the target of neutralizing antibody attack, and hence represents the only relevant viral antigen for antibody-based vaccine design. Various approaches have been attempted to recapitulate Env in membrane-anchored and soluble forms, and these will be discussed here in the context of recent successes and challenges still to be overcome.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.