Molecules | |
Conformational Analysis of Geometric Isomers of Pitavastatin Together with Their Lactonized Analogues | |
Damjan Makuc3  Jan Fabris2  Zdenko sar1  | |
[1] Sandoz Development Center Slovenia, API Development, Organic Synthesis Department, Lek Pharmaceuticals, d.d., Kolodvorska 27, Mengeš SI-1234, Slovenia; E-Mail:;Cadonic Consultancy Services, LL.C., Cesta na postajo 74, Brezovica pri Ljubljani SI-1351, Slovenia; E-Mail:;Slovenian NMR Centre, National Institute of Chemistry, Hajdrihova 19, Ljubljana SI-1000, Slovenia; E-Mail: | |
关键词: conformational analysis; intramolecular dynamics; NMR studies; barriers to rotation; super-statins; | |
DOI : 10.3390/molecules181113283 | |
来源: mdpi | |
【 摘 要 】
Super-statins are synthetic inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, which is the rate-limiting enzyme responsible for the biosynthesis of cholesterol. All of the super-statins with a C=C double bond spacer between the heterocyclic and the dihydroxycarboxylic moiety that are currently on the market exist as
【 授权许可】
CC BY
© 2013 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
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RO202003190031914ZK.pdf | 899KB | download |