Crambescidin-816 Acts as a Fungicidal with More Potency than Crambescidin-800 and -830, Inducing Cell Cycle Arrest, Increased Cell Size and Apoptosis in Saccharomyces cerevisiae

Marine Drugs

Juan A. Rubiolo³  Eva Ternon²  Henar López-Alonso³  Olivier P. Thomas²  Félix V. Vega¹  Mercedes R. Vieytes¹ 

[1] Department of Physiology, Faculty of Veterinary, University of Santiago de Compostela (USC), Campus Lugo, Lugo 27002, Spain; E-Mails:;Nice Institute of Chemistry-PCRE, UMR 7272 CNRS, Faculty of Sciences, University of Nice Sophia Antipolis, Parc Valrose 06108 Nice, France; E-Mails:;Department of Pharmacology, Faculty of Veterinary, University of Santiago de Compostela (USC), Campus Lugo, Lugo 27002, Spain; E-Mails:

关键词: crambescidine-816;    antifungal;    cell cycle arrest;    apoptosis;   

DOI  :  10.3390/md11114419

来源: mdpi

【 摘 要 】

In this paper, we show the effect of crambescidin-816, -800, and -830 on Saccharomyces cerevisiae viability. We determined that, of the three molecules tested, crambescidin-816 was the most potent. Based on this result, we continued by determining the effect of crambescidin-816 on the cell cycle of this yeast. The compound induced cell cycle arrest in G2/M followed by an increase in cell DNA content and size. When the type of cell death was analyzed, we observed that crambescidin-816 induced apoptosis. The antifungal effect indicates that crambescidins, and mostly crambescidin-816, could serve as a lead compound to fight fungal infections.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.