Penicillinolide A: A New Anti-Inflammatory Metabolite from the Marine Fungus Penicillium sp. SF-5292

Marine Drugs

Dong-Sung Lee³  Wonmin Ko³  Tran Hong Quang³  Kyoung-Su Kim³  Jae Hak Sohn²  Jae-Hyuk Jang¹  Jong Seog Ahn¹  Youn-Chul Kim³ 

[1] Chemical Biology Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 30 Yeongudanji-ro, Ochang, Cheongwon 363-883, Korea; E-Mails:;College of Medical and Life Sciences, Silla University, Busan 617-736, Korea; E-Mail:;Department of Pharmacy, College of Pharmacy, Wonkwang University, Iksan 570-749, Korea; E-Mails:

关键词: Penicillium sp.;    marine-derived fungi;    10-membered lactone;    anti-inflammatory effect;    heme oxygenase-1;   

DOI  :  10.3390/md11114510

来源: mdpi

【 摘 要 】

In the course of studies on bioactive metabolites from marine fungi, a new 10-membered lactone, named penicillinolide A (1) was isolated from the organic extract of Penicillium sp. SF-5292 as a potential anti-inflammatory compound. The structure of penicillinolide A (1) was mainly determined by analysis of NMR and MS data and Mosher’s method. Penicillinolide A (1) inhibited the production of NO and PGE₂ due to inhibition of the expression of iNOS and COX-2. Penicillinolide A (1) also reduced TNF-α, IL-1β and IL-6 production, and these anti-inflammatory effects were shown to be correlated with the suppression of the phosphorylation and degradation of IκB-α, NF-κB nuclear translocation, and NF-κB DNA binding activity. In addition, using inhibitor tin protoporphyrin (SnPP), a competitive inhibitor of HO activity, it was verified that the inhibitory effects of compound 1 on the production of pro-inflammatory mediators and NF-κB DNA binding activity were partially associated with HO-1 expression through Nrf2 nuclear translocation.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.