Metabolites | |
Metformin: On Ongoing Journey across Diabetes, Cancer Therapy and Prevention | |
Claudio Pulito2  Toran Sanli1  Punam Rana1  Paola Muti1  Giovanni Blandino3  | |
[1] Department of Oncology, Juravinski Cancer Center, McMaster University, Hamilton, ON L8V 5C2, Canada; E-Mails:;Molecular Chemoprevention Group, Molecular Medicine Area, Regina Elena National Institute, Rome 00144, Italy; E-Mail:;Translational Oncogenomics Unit-ROC, Molecular Medicine Area, Regina Elena National Institute, Rome 00144, Italy; E-Mail: | |
关键词: diabetes; cancer; microRNA; therapy; chemoprevention; metabolism; meta analysis; | |
DOI : 10.3390/metabo3041051 | |
来源: mdpi | |
【 摘 要 】
Cancer metabolism is the focus of intense research, which witnesses its key role in human tumors. Diabetic patients treated with metformin exhibit a reduced incidence of cancer and cancer-related mortality. This highlights the possibility that the tackling of metabolic alterations might also hold promising value for treating cancer patients. Here, we review the emerging role of metformin as a paradigmatic example of an old drug used worldwide to treat patients with type II diabetes which to date is gaining strong
【 授权许可】
CC BY
© 2013 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
Files | Size | Format | View |
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RO202003190031610ZK.pdf | 319KB | download |