The Ribonucleoprotein Csr Network

International Journal of Molecular Sciences

Ethel Seyll¹ 

[1] Laboratoire de Génétique et Physiologie Bactérienne, IBMM, Faculté des Sciences, Université Libre de Bruxelles (ULB), 12 rue des Professeurs Jeener et Brachet, B-6041 Gosselies, Belgium; E-Mail

关键词: Csr network;    Rsm network;    global regulation;    RNA-binding protein;    sRNAs;    post-transcriptional regulation;   

DOI  :  10.3390/ijms141122117

来源: mdpi

【 摘 要 】

Ribonucleoprotein complexes are essential regulatory components in bacteria. In this review, we focus on the carbon storage regulator (Csr) network, which is well conserved in the bacterial world. This regulatory network is composed of the CsrA master regulator, its targets and regulators. CsrA binds to mRNA targets and regulates translation either negatively or positively. Binding to small non-coding RNAs controls activity of this protein. Expression of these regulators is tightly regulated at the level of transcription and stability by various global regulators (RNAses, two-component systems, alarmone). We discuss the implications of these complex regulations in bacterial adaptation.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland