Preparation of Microcapsules Containing β-Carotene with Thermo Sensitive Curdlan by Utilizing Reverse Dispersion

Pharmaceutics

Yoshinari Taguchi²  Fumiyasu Ono¹ 

[1] Collaborative Research Division Art, Science and Technology Center for Cooperative Research, Kyushu University, 4-1, Kyudaishinmachi, Nishi-ku, Fukuoka 819-0388, Japan; E-Mail:;Department of Chemistry and Chemical Engineering, Niigata University, 8050, Ikarashi 2-nocho, Niigata-shi, Niigata 950-2181, Japan; E-Mail:

关键词: curdlan microcapsule;    reverse dispersion;    thermogelation;    β-carotene;    liquid liquid dispersion;   

DOI  :  10.3390/pharmaceutics5040609

来源: mdpi

【 摘 要 】

We have tried to microencapsulate β-carotene with curdlan of a thermogelation type polysaccharide. Microcapsules were prepared by utilizing reverse dispersion, in which salada oil was the continuous phase (O’) and the curdlan water slurry (W) was the dispersed phase. β-carotene (O) as a core material was broken into fine oil droplets in the dispersed phase to form the (O/W) dispersion. The (O/W) dispersion was poured in the continuous phase (O’) and stirred to form the (O/W)/O’ dispersion at room temperature and then, temperature of the dispersion was raised to 80 °C to prepare curdlan-microcapusles containing β-carotene. In this microencapsulation process, the concentrations of curdlan and oil soluble surfactant and the impeller speed to form the (O/W)/O’ dispersion were mainly changed stepwise. We were able to prepare microcapsules by the microencapsulation method adopted here. The content of core material was increased with the curdlan concentration and decreased with the impeller speed and the oil soluble surfactant concentration. With the curdlan concentration, the drying rate of microcapsules was decreased and the retention ability for water was increased due to the stable preservation of β-carotene.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.