Phenolic Composition, Antioxidant Activity and Anti-Adipogenic Effect of Hot Water Extract from Safflower (Carthamus tinctorius L.) Seed

Nutrients

Seok-Yeong Yu⁴  Young-Jun Lee⁴  Jong-Dai Kim⁴  Suk-Nam Kang⁵  Seong-Kap Lee²  Jung-Young Jang³  Hyo-Ku Lee³  Jeong-Ho Lim¹ 

[1] Korea Food Research Institute, Gyeonggi 463-746, Korea; E-Mail:;Department of Food and Biotechnology, Hoseo University, Asan 336-795, Korea; E-Mail:;Department of Food Science and Technology, Kongju National University, Yesan 340-800, Korea; E-Mails:;Department of Food Science and Biotechnology, Kangwon National University, Chuncheon 200-701, Korea; E-Mails:;Department of Animal Resources Technology, Gyeongnam National University of Science and Technology, Jinju 660-758, Korea; E-Mail:

关键词: antioxidant activity;    phenolic compound;    Carthamus tinctorius L. seed;    3T3-L1 adipocyte;    hot-water extract;   

DOI  :  10.3390/nu5124894

来源: mdpi

【 摘 要 】

This study was to evaluate the phenolic content and composition of Carthamus tinctorius L. seed extract (CSE) and to further assess its antioxidant and anti-adipogenic activities using various radical scavenging systems and 3T3-L1 cells. Our results show that the total phenolic and flavonoid contents of CSE were 126.0 ± 2.4 mg GAE/g and 62.2 ± 1.9 mg QE/g, respectively. The major phenolic compounds in CSE was (−)-epigallocatechin (109.62 mg/g), with a 4-hydroxy benzhydrazide derivative and gallocatechin present at 18.28 mg/g and 17.02 mg/g, respectively. CSE exhibited remarkable radical scavenging activities, FRAP (ferric reducing antioxidant power) and reducing power in a dose-dependent manner. Moreover, the oxygen radical absorbance capacity (ORAC) value of CSE (0.1 mg/mL) was 62.9 ± 4.7 μM TE (trolox equivalent)/g. During adipogenesis, CSE significantly inhibited fat accumulation in 3T3-L1 cells compared with control cells. Overall, these results indicate that CSE might be a valuable source of bioactive compounds that impart functional food and natural antioxidant properties.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.