Membrane Signaling Induced by High Doses of Ionizing Radiation in the Endothelial Compartment. Relevance in Radiation Toxicity

International Journal of Molecular Sciences

Isabelle Corre¹  Maëva Guillonneau² 

[1] CRCNA-UMR Inserm U892-CNRS 6299-Institut de Recherche en Santé de l’Université de Nantes, Nantes 44007, France;

关键词: radiotherapy;    radiation toxicity;    endothelium;    plasma membrane;    acid sphingomyelinase;    ceramide;   

DOI  :  10.3390/ijms141122678

来源: mdpi

【 摘 要 】

Tumor areas can now be very precisely delimited thanks to technical progress in imaging and ballistics. This has also led to the development of novel radiotherapy protocols, delivering higher doses of ionizing radiation directly to cancer cells. Despite this, radiation toxicity in healthy tissue remains a major issue, particularly with dose-escalation in these new protocols. Acute and late tissue damage following irradiation have both been linked to the endothelium irrigating normal tissues. The molecular mechanisms involved in the endothelial response to high doses of radiation are associated with signaling from the plasma membrane, mainly via the acid sphingomyelinase/ceramide pathway. This review describes this signaling pathway and discusses the relevance of targeting endothelial signaling to protect healthy tissues from the deleterious effects of high doses of radiation.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland