期刊论文详细信息
Molecules
Maternal High Fat Feeding Does Not Have Long-Lasting Effects on Body Composition and Bone Health in Female and Male Wistar Rat Offspring at Young Adulthood
Paula M. Miotto1  Laura M. Castelli1  Foyinsola Amoye1  Paul J. LeBlanc1  Sandra J. Peters1  Brian D. Roy1 
[1] Center for Bone and Muscle Health, Brock University, 500 Glenridge Avenue, St. Catharines, ON, L2S 3A1, Canada
关键词: bone mineral;    bone strength;    fatty acids;    high fat diet;    nutritional programming;    rats;   
DOI  :  10.3390/molecules181215094
来源: mdpi
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【 摘 要 】

High fat diets adversely affect body composition, bone mineral and strength, and alter bone fatty acid composition. It is unclear if maternal high fat (HF) feeding permanently alters offspring body composition and bone health. Female rats were fed control (CON) or HF diet for 10 weeks, bred, and continued their diets throughout pregnancy and lactation. Male and female offspring were studied at weaning and 3 months, following consumption of CON diet. At weaning, but not 3 months of age, male and female offspring from dams fed HF diet had lower lean mass and higher fat and bone mass, and higher femur bone mineral density (females only) than offspring of dams fed CON diet. Male and female offspring femurs from dams fed HF diet had higher monounsaturates and lower n6 polyunsaturates at weaning than offspring from dams fed CON diet, where females from dams fed HF diet had higher saturates and lower n6 polyunsaturates at 3 months of age. There were no differences in strength of femurs or lumbar vertebrae at 3 months of age in either male or female offspring. In conclusion, maternal HF feeding did not permanently affect body composition and bone health at young adulthood in offspring.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.

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