Polyketides from the Halotolerant Fungus Myrothecium sp. GS-17

Molecules

Tao Liu³  Jing Zhu⁴  Song-Ya Zhang⁵  Zhan-Lin Li⁵  Li-Ping Guan⁵  Hua-Qi Pan²  Xin Wu¹  Jiao Bai⁵ 

[1] School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, China; E-Mail:;Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang 110016, China; E-Mail:;Department of Natural Products Chemistry, School of Pharmacy, China Medical University, Shenyang 110001, China;State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071, China; E-Mail:;Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China; E-Mails:

关键词: halotolerant fungus;    Myrothecium sp.;    polyketide;    furanone;   

DOI  :  10.3390/molecules181215126

来源: mdpi

【 摘 要 】

Two new polyketides, myrothecol (1) and 5-hydroxy-3-methyl-4-(1- hydroxylethyl)-furan-2(5H)-one (2), were isolated from the fermentation broth of the halotolerant fungus Myrothecium sp. GS-17 along with three known compounds, 5-hydroxyl-3-[(1S)-1-hydroxyethyl]-4-methylfuran-2(5H)-one (3), 3,5-dimethyl-4- hydroxylmethyl-5-methoxyfuran-2(5H)-one (4), and 3,5-dimethyl-4-hydroxymethyl-5- hydroxyfuran-2(5H)-one (5). Compound 1 is the first natural occurring polyketide with a unique furylisobenzofuran skeleton. The structures of these compounds were established via extensive spectroscopic analyses including 1D-, 2D-NMR, HRESI-MS, and crystal X-ray diffraction analysis.

【 授权许可】

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