Thyroid Hormones and Antioxidant Systems: Focus on Oxidative Stress in Cardiovascular and Pulmonary Diseases

International Journal of Molecular Sciences

Antonio Mancini⁴  Sebastiano Raimondo⁴  Chantal Di Segni⁴  Mariasara Persano⁴  Giovanni Gadotti⁴  Andrea Silvestrini¹  Roberto Festa²  Luca Tiano³  Alfredo Pontecorvi⁴ 

[1] Institute of Biochemistry and Clinical Biochemistry, Catholic University, Rome 00168, Italy; E-Mails:;Department of Clinical and Molecular Science, Polytechnic University of the Marche, Ancona 60100, Italy; E-Mail:;Department of Clinical and Dental Sciences, Polytechnic University of Marche, Ancona 60100, Italy; E-Mail:;Department of Medical Sciences, Division of Endocrinology, Catholic University; Rome 00168, Italy; E-Mails:

关键词: oxidative stress;    coenzyme Q₁₀;    total antioxidant capacity;    thyroid hormones;    “low-T3” syndrome;   

DOI  :  10.3390/ijms141223893

来源: mdpi

【 摘 要 】

In previous works we demonstrated an inverse correlation between plasma Coenzyme Q₁₀ (CoQ₁₀) and thyroid hormones; in fact, CoQ₁₀ levels in hyperthyroid patients were found among the lowest detected in human diseases. On the contrary, CoQ₁₀ is elevated in hypothyroid subjects, also in subclinical conditions, suggesting the usefulness of this index in assessing metabolic status in thyroid disorders. A Low-T3 syndrome is a condition observed in several chronic diseases: it is considered an adaptation mechanism, where there is a reduction in pro-hormone T4 conversion. Low T3-Syndrome is not usually considered to be corrected with replacement therapy. We review the role of thyroid hormones in regulation of antioxidant systems, also presenting data on total antioxidant capacity and Coenzyme Q₁₀. Published studies suggest that oxidative stress could be involved in the clinical course of different heart diseases; our data could support the rationale of replacement therapy in low-T3 conditions.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland