Anti-Inflammatory Effects of 4-Methylcyclopentadecanone on Edema Models in Mice

International Journal of Molecular Sciences

Yukui Ma¹  Yue Li²  Xiufeng Li³ 

[1] Department of Pharmacology, Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang 110016, China; E-Mail:;Department of Pharmacy, Zhangqiu People’s Hospital, Huiquan Road 1920, Zhangqiu 250200, China; E-Mail:;Shandong Hongjitang Pharmaceutical Group Co., Ltd., Hualong Road 360, Jinan 250100, China; E-Mail:

关键词: 4-methylcyclopentadecanone;    inflammation;    paw edema;    ear edema;    toxicity;   

DOI  :  10.3390/ijms141223980

来源: mdpi

【 摘 要 】

The present study evaluated the anti-inflammatory effects of 4-methylcyclopentadecanone (4-MCPC) on edema models in mice and aimed to determine the safety of 4-MCPC after acute exposure. The acute toxicity of 4-MCPC was evaluated by oral administration to rats of single doses of 0, 5, 50, 500 and 5000 mg/kg. Toxic symptoms were observed for 14 days. The anti-inflammatory activity was evaluated in xylene-induced mouse ear edema and carrageenan-induced mouse paw edema. The animals were treated with 4-MCPC once every day for seven consecutive days. Edema index, % inhibition, IL-1β, TNF-α, PGE₂ and MPO levels in paws were detected after the treatment with xylene or carrageenan. Our results indicated that the LD₅₀ value of 4-MCPC in rats is greater than 5000 mg/kg. The ED₅₀ of 4-MCPC in xylene-induced mouse ear edema model was 7.5 mg/kg. 4-MCPC (8 or 16 mg/kg) remarkably inhibited carrageenan-induced mouse paw edema. Further study revealed that 4-MCPC treatment also decreased IL-1β, TNF-α, PGE₂ and MPO levels in mice paws. Intragastric administration of 4-MCPC exhibited more significant anti-inflammatory activity than muscone at a dose of 16 mg/kg. Taken together, our results suggest that 4-MCPC has potent anti-inflammatory activity and the mechanisms might be related to the decreases of the levels of IL-1β, TNF-α, PGE₂ and MPO in inflamed paws.

【 授权许可】

CC BY   
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