Vascular Endothelial Growth Factor Levels in Dobrava/Belgrade Virus Infections

Viruses

Katerina Tsergouli¹ 

[1] Department of Microbiology, Medical School, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece; E-Mail

关键词: vascular endothelial growth factor;    Dobrava/Belgrade virus;    hemorrhagic fever with renal syndrome;    hantavirus;    Greece;   

DOI  :  10.3390/v5123109

来源: mdpi

【 摘 要 】

The levels of vascular endothelial growth factor-A (VEGF) were estimated in 102 serum samples from 63 hospitalized Greek patients with hemorrhagic fever with renal syndrome (HFRS) caused by Dobrava/Belgrade virus. Significantly higher VEGF levels were seen in the severe when compared with non-severe cases (mean values 851.96 pg/mL and 326.75 pg/mL, respectively; p = 0.003), while a significant difference was observed among groups based on the day after the onset of illness. In both severe and non-severe cases, VEGF peaked in the second week of illness; however, elevation of VEGF in the severe cases started later and remained high until convalescence, suggesting that the role of VEGF was associated with repair of vascular damage rather than with increased permeability.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.