Regenerative Medicine for Epilepsy: From Basic Research to Clinical Application

International Journal of Molecular Sciences

Takao Yasuhara¹  Takashi Agari¹  Masahiro Kameda¹  Akihiko Kondo¹  Satoshi Kuramoto¹  Meng Jing¹  Tatsuya Sasaki¹  Atsuhiko Toyoshima¹  Susumu Sasada¹  Kenichiro Sato¹  Aiko Shinko¹  Takaaki Wakamori¹  Yu Okuma¹  Yasuyuki Miyoshi¹  Naoki Tajiri²  Cesario V. Borlongan² 

[1]Department of Neurological Surgery, Okayama University Graduate School of Medicine, 2-5-1, Shikata-cho, Okayama 700-8558, Japan

[2] E-Mails:

[3]Department of Neurosurgery, University of South Florida College Medicine, 12901 Bruce B Downs Blvd, Tampa, FL 33612, USA

[4] E-Mails:

关键词: brain-derived neurotrophic factor (BDNF);    electrical stimulation;    erythropoietin;    GABAergic neuron;    kainic acid;    kindling;    neural stem cell;   

DOI  :  10.3390/ijms141223390

来源: mdpi

【 摘 要 】

Epilepsy is a chronic neurological disorder, which presents with various forms of seizures. Traditional treatments, including medication using antiepileptic drugs, remain the treatment of choice for epilepsy. Recent development in surgical techniques and approaches has improved treatment outcomes. However, several epileptic patients still suffer from intractable seizures despite the advent of the multimodality of therapies. In this article, we initially provide an overview of clinical presentation of epilepsy then describe clinically relevant animal models of epilepsy. Subsequently, we discuss the concepts of regenerative medicine including cell therapy, neuroprotective agents, and electrical stimulation, which are reviewed within the context of our data.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland