Marine Drugs | |
Screening Mangrove Endophytic Fungi for Antimalarial Natural Products | |
Laurent Calcul4  Carrie Waterman4  Wai Sheung Ma4  Matthew D. Lebar4  Charles Harter4  Tina Mutka3  Lindsay Morton3  Patrick Maignan3  Alberto Van Olphen3  Dennis E. Kyle3  Lilian Vrijmoed2  Ka-Lai Pang1  Cedric Pearce5  | |
[1] Institute of Marine Biology and Center of Excellence for the Oceans, National Taiwan Ocean University, 2 Pei-Ning Road, Keelung 20224, Taiwan; E-Mail:;Department of Biology and Chemistry, City University of Hong Kong, 83 Tat Chee Avenue, Hong Kong, China; E-Mail:;Department of Global Health, University of South Florida, 3720 Spectrum Blvd., Suite 304, Tampa, FL 33612, USA; E-Mails:;Department of Chemistry, University of South Florida, 4202 E. Fowler, CHE 205, Tampa, FL 33620, USA; E-Mails:;Mycosynthetix, Inc., 505 Meadowlands Drive, Suite 103, Hillsborough, NC 27278, USA; E-Mail: | |
关键词: fungi; endophytes; mangroves; malaria; cytotoxicity; high-throughput; | |
DOI : 10.3390/md11125036 | |
来源: mdpi | |
【 摘 要 】
We conducted a screening campaign to investigate fungi as a source for new antimalarial compounds. A subset of our fungal collection comprising Chinese mangrove endophytes provided over 5000 lipophilic extracts. We developed an accelerated discovery program based on small-scale cultivation for crude extract screening and a high-throughput malaria assay. Criteria for hits were developed and high priority hits were subjected to scale-up cultivation. Extracts from large scale cultivation were fractionated and these fractions subjected to both
【 授权许可】
CC BY
© 2013 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
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RO202003190030882ZK.pdf | 582KB | download |