Identification of Four New agr Quorum Sensing-Interfering Cyclodepsipeptides from a Marine Photobacterium

Marine Drugs

Louise Kjaerulff²  Anita Nielsen¹  Maria Mansson³  Lone Gram³  Thomas O. Larsen³  Hanne Ingmer¹ 

[1] Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen, DK-1870 Frederiksberg C, Denmark; E-Mail:;Department of Chemistry, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark; E-Mail:;Department of Systems Biology, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark; E-Mails:

关键词: Photobacterium;    depsipeptide;    structure elucidation;    quorum sensing;    antivirulence;    agr;   

DOI  :  10.3390/md11125051

来源: mdpi

【 摘 要 】

During our search for new natural products from the marine environment, we discovered a wide range of cyclic peptides from a marine Photobacterium, closely related to P. halotolerans. The chemical fingerprint of the bacterium showed primarily non-ribosomal peptide synthetase (NRPS)-like compounds, including the known pyrrothine antibiotic holomycin and a wide range of peptides, from diketopiperazines to cyclodepsipeptides of 500–900 Da. Purification of components from the pellet fraction led to the isolation and structure elucidation of four new cyclodepsipeptides, ngercheumicin F, G, H, and I. The ngercheumicins interfered with expression of virulence genes known to be controlled by the agr quorum sensing system of Staphylococcus aureus, although to a lesser extent than the previously described solonamides from the same strain of Photobacterium.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.