Madecassoside Inhibits Melanin Synthesis by Blocking Ultraviolet-Induced Inflammation

Molecules

Eunsun Jung²  Jung-A Lee²  Seoungwoo Shin²  Kyung-Baeg Roh²  Jang-Hyun Kim¹ 

[1] Dermiskin Life Science Institute, 44-9 Cheongho Ri, Pyeongtaek City, 451-862 Gyunggi Do, Korea; E-Mail:;Biospectrum Life Science Institute, Eines Platz 11th FL, 442-13 Sangdaewon Dong, Seongnam City, 462-807 Gyunggi Do, Korea; E-Mail:

关键词: post-inflammatory pigmentation;    madecassoside;    PAR-2;    UVR;   

DOI  :  10.3390/molecules181215724

来源: mdpi

【 摘 要 】

Madecassoside (MA), a pentacyclic triterpene isolated from Centella asitica (L.), is used as a therapeutic agent in wound healing and also as an anti-inflammatory and anti-aging agent. However, the involvement of MA in skin-pigmentation has not been reported. This study was conducted to investigate the effects of MA on ultraviolet (UV)-induced melanogenesis and mechanisms in a co-culture system of keratinocytes and melanocytes. MA significantly inhibited UVR-induced melanin synthesis and melanosome transfer in the co-culture system. These effects were further demonstrated by the MA-induced inhibition of protease-activated receptor-2 expression and its signaling pathway, cyclooxygenase-2, prostaglandin E2 and prostaglandin F2 alpha in keratinocytes. The clinical efficacy of MA was confirmed on artificially tanned human skin. MA significantly reduced UV-induced melanin index at 8 weeks after topical application. Overall, the study demonstrated significant benefits of MA use in the inhibition of hyperpigmentation caused by UV irradiation.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.