International Journal of Molecular Sciences | |
Maternal Methyl Donors Supplementation during Lactation Prevents the Hyperhomocysteinemia Induced by a High-Fat-Sucrose Intake by Dams | |
Paul Cordero1  Fermin I. Milagro1  Javier Campion1  | |
[1] Department of Nutrition, Food Science and Physiology, University of Navarra, 31008 Pamplona, Spain; E-Mails: | |
关键词: cardiovascular; HFS diet; homocysteine; maternal programming; methyl donors; obesity; | |
DOI : 10.3390/ijms141224422 | |
来源: mdpi | |
【 摘 要 】
Maternal perinatal nutrition may program offspring metabolic features. Epigenetic regulation is one of the candidate mechanisms that may be affected by maternal dietary methyl donors intake as potential controllers of plasma homocysteine levels. Thirty-two Wistar pregnant rats were randomly assigned into four dietary groups during lactation: control, control supplemented with methyl donors, high-fat-sucrose and high-fat-sucrose supplemented with methyl donors. Physiological outcomes in the offspring were measured, including hepatic mRNA expression and global DNA methylation after weaning. The newborns whose mothers were fed the obesogenic diet were heavier longer and with a higher adiposity and intrahepatic fat content. Interestingly, increased levels of plasma homocysteine induced by the maternal high-fat-sucrose dietary intake were prevented in both sexes by maternal methyl donors supplementation. Total hepatic DNA methylation decreased in females due to maternal methyl donors administration, while
【 授权许可】
CC BY
© 2013 by the authors; licensee MDPI, Basel, Switzerland
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