New Dimeric Members of the Phomoxanthone Family: Phomolactonexanthones A, B and Deacetylphomoxanthone C Isolated from the Fungus Phomopsis sp.

Marine Drugs

Bo Ding³  Jie Yuan²  Xishan Huang³  Weitao Wen²  Xu Zhu²  Yayue Liu³  Hanxiang Li³  Yongjun Lu¹  Lei He¹  Hongmei Tan² 

[1] School of Life Sciences and Biomedical Center, Sun Yat-sen University, 135 Xingang West Road, Guangzhou 510275, China; E-Mails:;Zhongshan School of Medicine, Sun Yat-sen University, 74 Zhongshan Road II, Guangzhou 510080, China; E-Mails:;School of Chemistry and Chemical Engineering, Sun Yat-sen University, 135 Xingang West Road, Guangzhou 510275, China; E-Mails:

关键词: Mangrove;    Phomopsis sp.;    Phomoxanthones;    phomolactonexanthones;    decetylphomoxanthone C;    MTT assay;   

DOI  :  10.3390/md11124961

来源: mdpi

【 摘 要 】

Three new phomoxanthone compounds, phomolactonexanthones A (1), B (2) and deacetylphomoxanthone C (3), along with five known phomoxanthones, including dicerandrol A (4), dicerandrol B (5), dicerandrol (6), deacetylphomoxanthone B (7) and penexanthone A (8), were isolated in the metabolites of the fungus Phomopsis sp. HNY29-2B, which was isolated from the mangrove plants. The structures of compounds 1–3 were established on the basis of spectroscopic analysis. All compounds were evaluated against four human cancer cell lines including human breast MDA-MB-435, human colon HCT-116, human lung Calu-3 and human liver Huh7 by MTT assay. The compounds 4, 5, 7 and 8 showed cyctotoxic activities against tested cancer cell lines (IC₅₀ < 10 μM).

【 授权许可】

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