Crystal Structures and Antifungal Activities of Fluorine-Containing Thioureido Complexes with Nickel(II)

Molecules

Chun Li³  Wen Yang¹  Huanhuan Liu¹  Mengying Li²  Weiqun Zhou¹ 

[1] College of Chemistry, Chemical Engineering and Materials Science, Soochow University, 199 Ren’ai Road, Suzhou 215123, China;School of Biology & Basic Medical Sciences, Soochow University, 199 Ren’ai Road, Suzhou 215123, China;College of Pharmacy, Nantong Tichen Health School, Nantong 226007, China

关键词: fluorobenzoyl thioureas;    Ni(II) complexes;    crystal structures;    antifungal activity;   

DOI  :  10.3390/molecules181215737

来源: mdpi

【 摘 要 】

Ni(II) complexes with N-2-fluorobenzoylpiperidine-1-carbothioimidate (L2⁻), N-4-fluorobenzoylpiperidine-1-carbothioimidate (L3⁻), N-2-fluorobenzoylmorpholine- 1-carbothioimidate (L5⁻) and N-4-fluorobenzoylmorpholine-1-carbothioimidate (L6⁻) have been synthesized and characterized by elemental analysis, FTIR and ¹H-NMR. The crystal structures of three ligands (HL2, HL3 and HL6) and the corresponding Ni(II) complexes ([Ni(L2)₂], [Ni(L3)₂] and [Ni(L6)₂]) have been determined by X-ray diffraction. The antifungal activities of the Ni(II) complexes together and the corresponding ligands against the fungi Botrytis cinerea, Trichoderma spp., Myrothecium and Verticillium spp. have been investigated. The experimental results showed that the ligands and their complexes have antifungal abilities. When the fluorine was substituted on the para-benzoyl moiety, the antifungal activity of the ligands was obviously increased. Moreover, the ligands were stronger than their complexes in inhibiting fungal activities. The antifungal ability of HL6 is especially strong, and similar to that of the commercial fungicide fluconazole.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.