Asymmetric Synthesis of 4,1-Benzoxazepine-2,5-Diones — Effect of the Halogen of (2S)-α-Haloacids

Molecules

Syeda Laila Rubab¹  Bushra Nisar¹  Abdul Rauf Raza¹  Nisar Ullah² 

[1] Ibn-e-Sina Block, Department of Chemistry, University of Sargodha, Sargodha 40100, Pakistan; E-Mails:;Chemistry Department, King Fahd University of Petroleum and Minerals, Dhahran 31261, Saudi Arabia

关键词: (3R)-3-alkyl-4;    1-benzoxazepine-2;    5-diones;    asymmetric synthesis;    α-chloroacids;    α-bromoacids;    anthranilic acid;    chiral pool methodology;   

DOI  :  10.3390/molecules19010139

来源: mdpi

【 摘 要 】

Novel chiral 4,1-benzoxazepine-2,5-diones have been unusually synthesized in a single step by exploiting the chiral pool methodology. Substituted anthranilic acids afford N-acylanthranilic acids and (3R)-3-alkyl-4,1-benzoxazepines-2,5-dione upon coupling with α-chloroacids or α-bromoacids, respectively.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.