International Journal of Molecular Sciences | |
Pharmacokinetic Comparison of Berberine in Rat Plasma after Oral Administration of Berberine Hydrochloride in Normal and Post Inflammation Irritable Bowel Syndrome Rats | |
Zipeng Gong2  Ying Chen2  Ruijie Zhang2  Yinghan Wang2  Yan Guo2  Qing Yang2  Haixian Zhang3  Yu Dong1  Xiaogang Weng2  Shuangrong Gao2  | |
[1] Guang’an Men Hospital, China Academy of Chinese Medical Sciences, No.5, Beixiange Road, Xicheng District, Beijing 100053, China; E-Mail:;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, No.16, Dongzhimen Nei Nanxiao Road, Dongcheng District, Beijing 100700, China; E-Mails:;Institute of Ethnic Medicine, Southwest University, Chengdu 610041, China; E-Mail: | |
关键词: berberine; pharmacokinetic; absorption; irritable bowel syndrome; | |
DOI : 10.3390/ijms15010456 | |
来源: mdpi | |
【 摘 要 】
In the present study, post inflammation irritable bowel syndrome (PI-IBS) rats were firstly established by intracolonic instillation of acetic acid with restraint stress. Then the pharmacokinetics of berberine in the rat plasma were compared after oral administration of berberine hydrochloride (25 mg/kg) to normal rats and PI-IBS rats. Quantification of berberine in the rat plasma was achieved by using a sensitive and rapid UPLC-MS/MS method. Plasma samples were collected at 15 different points in time and the pharmacokinetic parameters were analyzed by WinNonlin software. Compared with the normal group, area under the plasma concentration
【 授权许可】
CC BY
© 2014 by the authors; licensee MDPI, Basel, Switzerland
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