Association between Serum 25-Hydroxyvitamin D and Inflammatory Cytokines in Healthy Adults

Nutrients

Xiaomin Sun²  Zhen-Bo Cao¹  Yuping Zhang²  Yoshiko Ishimi³  Izumi Tabata⁴ 

[1] Faculty of Sport Sciences, Waseda University, Tokorozawa, Saitama 359-1192, Japan; E-Mail:;Graduate School of Sport Sciences, Waseda University, Tokorozawa, Saitama 359-1192, Japan; E-Mails:;National Institute of Health and Nutrition, Tokyo 162-8636, Japan; E-Mail:;Faculty of Sport and Health Science, Ritsumeikan University, Kusatsu, Shiga 525-8577, Japan; E-Mail:

关键词: vitamin D;    interferon-γ;    interleukin-6;    interleukin-17;    physical activity;   

DOI  :  10.3390/nu6010221

来源: mdpi

【 摘 要 】

Here, we aimed to examine the associations between levels of serum 25-hydroxyvitamin D [25(OH)D] and inflammatory cytokines in healthy Japanese adults. A total of 95 healthy adults (61 women; age range 21–69 years) participated in our study. Fasting blood samples were analyzed for 25(OH)D, 1,25-dihydroxyvitamin D [1,25(OH)₂D], interferon-γ (IFN-γ), interleukin-6 (IL-6), and interleukin-17 (IL-17) levels using enzyme-linked immunosorbent assays kits. Total percent body fat was determined by dual energy X-ray absorptiometry (DXA). Moderate to vigorous physical activity (MVPA) was assessed objectively using an activity monitor for 7 days. The mean 25(OH)D concentration was 34.7 nmol/L, and 83 subjects had 25(OH)D concentrations less than 50 nmol/L. Multiple linear regression analysis revealed that serum 25(OH)D level was positively related to plasma IL-17 level (β = 0.26, p = 0.025), after adjustment for gender, age, vitamin D intake, alcohol consumption, smoking status, and percent body fat. This relationship remained statistically significant (β = 0.28, p = 0.019) even after additional adjustment for MVPA. However, no significant association was found between serum 25(OH)D level and plasma IFN-γ or IL-6 levels. In conclusion, this study identified a high prevalence of vitamin D deficiency in healthy Japanese adults. Serum 25(OH)D level was positively related to IL-17 level, independent of physical activity.

【 授权许可】

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© 2014 by the authors; licensee MDPI, Basel, Switzerland.