Nutrients | |
Iron Transport through Ferroportin Is Induced by Intracellular Ascorbate and Involves IRP2 and HIF2α | |
Nathalie Scheers1  | |
关键词: ascorbate; iron; ferroportin; IRP2; HIF2α; | |
DOI : 10.3390/nu6010249 | |
来源: mdpi | |
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【 摘 要 】
A few tightly regulated transport proteins mediate iron absorption across the intestinal epithelium. At the basolateral border of intestinal cells there is one identified transporter, ferroportin, for the transfer of intracellular iron to the vascular system. Here, we investigate the effects of ascorbate (vitamin C) on the regulation of ferroportin in human intestinal Caco-2 cells using ELISA and Western Blot analyses. The results indicate that ferroportin protein levels peak at 100 μM of added ascorbate with an increase of 274% (
【 授权许可】
CC BY
© 2014 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
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RO202003190030218ZK.pdf | 1441KB | ![]() |