ABSL-4 Aerobiology Biosafety and Technology at the NIH/NIAID Integrated Research Facility at Fort Detrick

Viruses

Matthew G. Lackemeyer¹  Fabian de Kok-Mercado¹  Jiro Wada¹  Laura Bollinger¹  Jason Kindrachuk¹  Victoria Wahl-Jensen¹  Jens H. Kuhn¹ 

[1] Integrated Research Facility at Fort Detrick, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick, Frederick, MD 21702, USA;

关键词: ABSL-4;    aerobiology;    biosafety level 4;    class III biosafety cabinet;    BSL-4;    high-consequence viral pathogens;    medical countermeasure;    viral hemorrhagic fever;   

DOI  :  10.3390/v6010137

来源: mdpi

【 摘 要 】

The overall threat of a viral pathogen to human populations is largely determined by the modus operandi and velocity of the pathogen that is transmitted among humans. Microorganisms that can spread by aerosol are considered a more challenging enemy than those that require direct body-to-body contact for transmission, due to the potential for infection of numerous people rather than a single individual. Additionally, disease containment is much more difficult to achieve for aerosolized viral pathogens than for pathogens that spread solely via direct person-to-person contact. Thus, aerobiology has become an increasingly necessary component for studying viral pathogens that are naturally or intentionally transmitted by aerosol. The goal of studying aerosol viral pathogens is to improve public health preparedness and medical countermeasure development. Here, we provide a brief overview of the animal biosafety level 4 Aerobiology Core at the NIH/NIAID Integrated Research Facility at Fort Detrick, Maryland, USA.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.