Biochemical and Genetic Engineering of Diatoms for Polyunsaturated Fatty Acid Biosynthesis

Marine Drugs

Hong-Ye Li¹  Yang Lu²  Jian-Wei Zheng²  Wei-Dong Yang² 

[1] Key Laboratory of Eutrophication and Red Tide Prevention of Guangdong Higher Education Institutes, Jinan University, Guangzhou 510632, China;

关键词: diatom;    fatty acids;    PUFA;    genetic engineering;   

DOI  :  10.3390/md12010153

来源: mdpi

【 摘 要 】

The role of diatoms as a source of bioactive compounds has been recently explored. Diatom cells store a high amount of fatty acids, especially certain polyunsaturated fatty acids (PUFAs). However, many aspects of diatom metabolism and the production of PUFAs remain unclear. This review describes a number of technical strategies, such as modulation of environmental factors (temperature, light, chemical composition of culture medium) and culture methods, to influence the content of PUFAs in diatoms. Genetic engineering, a newly emerging field, also plays an important role in controlling the synthesis of fatty acids in marine microalgae. Several key points in the biosynthetic pathway of PUFAs in diatoms as well as recent progresses are also a critical part and are summarized here.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.