Toxins | |
Methylglyoxal (MG) and Cerebro-Renal Interaction: Does Long-Term Orally Administered MG Cause Cognitive Impairment in Normal Sprague-Dawley Rats? | |
Kimio Watanabe3  Kana Okada2  Ryoji Fukabori1  Yoshimitsu Hayashi3  Koichi Asahi3  Hiroyuki Terawaki3  Kazuto Kobayashi1  Tsuyoshi Watanabe3  | |
[1] Department of Molecular Genetics, Institute of Biomedical Sciences, School of Medicine, Fukushima Medical University, 1 Hikarigaoka, Fukushima 960-1295, Japan; E-Mails:;Graduate School of Integrated Arts and Sciences, Hiroshima University, 1-7-1 Kagamiyama, Higashi-Hiroshima 739-8521, Japan; E-Mail:;Department of Nephrology, Hypertension, Diabetology, Endocrinology and Metabolism, School of Medicine, Fukushima Medical University, 1 Hikarigaoka, Fukushima 960-1295, Japan; E-Mails: | |
关键词: cerebro-renal interaction; methylglyoxal; cognitive impairment; chronic kidney disease; | |
DOI : 10.3390/toxins6010254 | |
来源: mdpi | |
【 摘 要 】
Methylglyoxal (MG), one of the uremic toxins, is a highly reactive alpha-dicarbonyl compound. Recent clinical studies have demonstrated the close associations of cognitive impairment (CI) with plasma MG levels and presence of kidney dysfunction. Therefore, the present study aims to examine whether MG is a direct causative substance for CI development. Eight-week-old male Sprague-Dawley (SD) rats were divided into two groups: control (
【 授权许可】
CC BY
© 2014 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
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