Polymers for Protein Conjugation

Polymers

关键词: protein delivery;    PEGylation;    polymer conjugation;    dextran;    hyaluronic acid;    polysialic acid;    dextrin;    poly(2-ethyl 2-oxazoline);   

DOI  :  10.3390/polym6010160

来源: mdpi

【 摘 要 】

Polyethylene glycol (PEG) at the moment is considered the leading polymer for protein conjugation in view of its unique properties, as well as to its low toxicity in humans, qualities which have been confirmed by its extensive use in clinical practice. Other polymers that are safe, biodegradable and custom-designed have, nevertheless, also been investigated as potential candidates for protein conjugation. This review will focus on natural polymers and synthetic linear polymers that have been used for protein delivery and the results associated with their use. Genetic fusion approaches for the preparation of protein-polypeptide conjugates will be also reviewed and compared with the best known chemical conjugation ones.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.