Proton Radiotherapy for Pediatric Sarcoma

Cancers

Matthew M. Ladra¹ 

[1] Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA; E-Mail

关键词: sarcoma;    pediatrics;    protons;    ewings;    osteosarcoma;    rhabdomyosarcoma;    chordoma;    chondrosarcoma;   

DOI  :  10.3390/cancers6010112

来源: mdpi

【 摘 要 】

Pediatric sarcomas represent a distinct group of pathologies, with approximately 900 new cases per year in the United States alone. Radiotherapy plays an integral role in the local control of these tumors, which often arise adjacent to critical structures and growing organs. The physical properties of proton beam radiotherapy provide a distinct advantage over standard photon radiation by eliminating excess dose deposited beyond the target volume, thereby reducing both the dose of radiation delivered to non-target structures as well as the total radiation dose delivered to a patient. Dosimetric studies comparing proton plans to IMRT and 3D conformal radiation have demonstrated the superiority of protons in numerous pediatric malignancies and data on long-term clinical outcomes and toxicity is emerging. In this article, we review the existing clinical and dosimetric data regarding the use of proton beam radiation in malignant bone and soft tissue sarcomas.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.