Luteolin Reduces Alzheimer’s Disease Pathologies Induced by Traumatic Brain Injury

International Journal of Molecular Sciences

Darrell Sawmiller¹  Song Li³  Md Shahaduzzaman²  Adam J. Smith²  Demian Obregon¹  Brian Giunta³  Cesar V. Borlongan²  Paul R. Sanberg² 

[1] James A. Haley Veteran’s Administration Hospital, Tampa, FL 33612, USA;Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, Morsani College of Medicine, University of South Florida, Tampa, FL 33613, USA; E-Mails:;Department of Psychiatry, Morsani College of Medicine, University of South Florida, Tampa, FL 33613, USA; E-Mails:

关键词: traumatic brain injury;    Alzheimer’s disease;    amyloidogenesis;    tauopathy;    GSK;    neuroinflammation;    luteolin;   

DOI  :  10.3390/ijms15010895

来源: mdpi

【 摘 要 】

Traumatic brain injury (TBI) occurs in response to an acute insult to the head and is recognized as a major risk factor for Alzheimer’s disease (AD). Indeed, recent studies have suggested a pathological overlap between TBI and AD, with both conditions exhibiting amyloid-beta (Aβ) deposits, tauopathy, and neuroinflammation. Additional studies involving animal models of AD indicate that some AD-related genotypic determinants may be critical factors enhancing temporal and phenotypic symptoms of TBI. Thus in the present study, we examined sub-acute effects of moderate TBI delivered by a gas-driven shock tube device in Aβ depositing Tg2576 mice. Three days later, significant increases in b-amyloid deposition, glycogen synthase-3 (GSK-3) activation, phospho-tau, and pro-inflammatory cytokines were observed. Importantly, peripheral treatment with the naturally occurring flavonoid, luteolin, significantly abolished these accelerated pathologies. This study lays the groundwork for a safe and natural compound that could prevent or treat TBI with minimal or no deleterious side effects in combat personnel and others at risk or who have experienced TBI.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland