Sensors | |
Topoisomerase I as a Biomarker: Detection of Activity at the Single Molecule Level | |
Joanna Proszek1  Amit Roy2  Ann-Katrine Jakobsen1  Rikke Frøhlich2  Birgitta R. Knudsen2  | |
[1] Department of Pathology, Aarhus University Hospital, Aarhus C 8000, Denmark; E-Mails:;Department of Molecular Biology and Genetics, Aarhus University, Aarhus C 8000, Denmark; E-Mails: | |
关键词: Topoisomerase-I; camptothecin; enzyme activity; biosensor; tyrosyl-DNA phosphodiesterase 1; single molecule; drug response; cancer; | |
DOI : 10.3390/s140101195 | |
来源: mdpi | |
【 摘 要 】
Human topoisomerase I (hTopI) is an essential cellular enzyme. The enzyme is often upregulated in cancer cells, and it is a target for chemotherapeutic drugs of the camptothecin (CPT) family. Response to CPT-based treatment is dependent on hTopI activity, and reduction in activity, and mutations in hTopI have been reported to result in CPT resistance. Therefore,
【 授权许可】
CC BY
© 2014 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
Files | Size | Format | View |
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RO202003190029910ZK.pdf | 369KB | download |