Marine Drugs | |
Trabectedin and Plitidepsin: Drugs from the Sea that Strike the Tumor Microenvironment | |
Carlos M. Galmarini2  Maurizio D’Incalci1  | |
[1]Department of Oncology, IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Milan 20156, Italy | |
[2] E-Mail: | |
[3]Cell Biology and Pharmacogenomics Department, PharmaMar, Madrid 28770, Spain | |
[4] E-Mail: | |
关键词: trabectedin; plitidepsin; tumor-associated macrophages; tumor microenvironment; | |
DOI : 10.3390/md12020719 | |
来源: mdpi | |
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【 摘 要 】
The prevailing paradigm states that cancer cells acquire multiple genetic mutations in oncogenes or tumor suppressor genes whose respective activation/up-regulation or loss of function serve to impart aberrant properties, such as hyperproliferation or inhibition of cell death. However, a tumor is now considered as an organ-like structure, a complex system composed of multiple cell types (e.g., tumor cells, inflammatory cells, endothelial cells, fibroblasts,
【 授权许可】
CC BY
© 2014 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
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RO202003190029871ZK.pdf | 649KB | ![]() |