RGD-Functionalization of Poly(2-oxazoline)-Based Networks for Enhanced Adhesion to Cancer Cells

Polymers

Verena Schenk³  Elisabeth Rossegger³  Clemens Ebner³  Florian Bangerl²  Klaus Reichmann²  Björn Hoffmann¹  Michael Höpfner¹ 

[1] Institute of Physiology, Charité, Universitätsmedizin Berlin, Campus Charité Mitte, Charitéplatz 1, Berlin 10117, Germany; E-Mail:;Institute for Chemistry and Technology of Materials, Graz University of Technology, Stremayrgasse 9, Graz 8010, Austria; E-Mails:;Polymer Competence Center Leoben GmbH PCCL, Roseggerstrasse 12, Leoben 8700, Austria; E-Mails:

关键词: poly(2-oxazoline)s;    crosslinked polymer networks;    RGD interaction with integrins;    cancer cell recognition;   

DOI  :  10.3390/polym6020264

来源: mdpi

【 摘 要 】

Poly(2-oxazoline) networks with varying swelling degrees and varying hydrophilicity can be synthesized from 2-ethyl-2-oxazoline, 2-nonyl-2-oxazoline, 2-9’-decenyl-2-oxazoline and 2,2’-tetramethylene-bis-2-oxazoline in one-pot/one-step strategies. These gels can be loaded with organic molecules, such as fluorescein isothiocyanate, either during the polymerization (covalent attachment of the dye) or according to post-synthetic swelling/deswelling strategies (physical inclusion of the dye). Surface functionalization of ground gels by thiol-ene reactions with cysteine-bearing peptides exhibiting the arginine-glycine-aspartic acid (RGD) motif yields microparticles with enhanced recognition of human cancer cells compared to healthy endothelial cells.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.