Solwaric Acids A and B, Antibacterial Aromatic Acids from a Marine Solwaraspora sp.

Marine Drugs

Gregory A. Ellis¹  Thomas P. Wyche¹  Charles G. Fry²  Doug R. Braun¹ 

[1] Pharmaceutical Sciences Division, University of Wisconsin-Madison, 777 Highland Avenue, Madison, WI 53705, USA; E-Mails:;Department of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, WI 53706, USA; E-Mail:

关键词: Trididemnum orbiculatum;    Solwaraspora;    methicillin-resistant Staphylococcus aureus;   

DOI  :  10.3390/md12021013

来源: mdpi

【 摘 要 】

Two novel trialkyl-substituted aromatic acids, solwaric acids A and B, were isolated from a marine Solwaraspora sp. cultivated from the ascidian Trididemnum orbiculatum. Solwaric acids A and B were isotopically labeled with U-¹³C glucose, and analysis of a ¹³C–¹³C COSY allowed for unambiguous determination of the location of the phenyl methyl group. The two novel compounds demonstrated antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-sensitive Staphylococcus aureus (MSSA).

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.