trans-11 18:1 Vaccenic Acid (TVA) Has a Direct Anti-Carcinogenic Effect on MCF-7 Human Mammary Adenocarcinoma Cells

Nutrients

Ji-Na Lim¹  Jin-Ju Oh⁴  Tao Wang²  Jae-Sung Lee¹  Sang-Hun Kim³  Yoon-Jin Kim³ 

[1] Department of Animal Science and Technology, College of Animal Bioscience & Technology, Konkuk University, Seoul 143-701, Korea; E-Mails:;College of Animal Science and Technology, Jilin Agricultural University, Changchun 130118, China; E-Mail:;Department of Biology, Kyung Hee University, Seoul 130-701, South Korea; E-Mails:;Natural Product Clinical Research Center, Clinical Research Center, Pusan National University School of Medicine, Busan 602-739, Korea; E-Mail:

关键词: apoptotic protein;    cancer cells;    cis-9;    trans-11conjugated linoleic acid;    stearoyl CoA desaturase;    trans fatty acids;   

DOI  :  10.3390/nu6020627

来源: mdpi

【 摘 要 】

Trans vaccenic acid (TVA; trans-11 18:1) is a positional and geometric isomer of oleic acid and it is the predominant trans isomer found in ruminant fats. TVA can be converted into cis-9, trans-11 conjugated linoleic acid (c9, t11-CLA), a CLA isomer that has many beneficial effects, by stearoyl CoA desaturase 1 (SCD1) in the mammary gland. The health benefits associated with CLA are well documented, but it is unclear whether trans fatty acids (TFAs) from ruminant products have healthy effects. Therefore, the effects of TVA on the proliferation of MCF-7 human breast adenocarcinoma cells and MCF-10A human breast epithelial cells were investigated in the present study. Results showed that TVA inhibited the proliferation of MCF-7 cells but not MCF-10A cells by down-regulating the expression of Bcl-2 as well as procaspase-9. In addition, the suppressive effect of TVA was confirmed in SCD1-depleted MCF-7 cells. Our results suggested that TVA exerts a direct anti-carcinogenic effect on MCF-7 cells. These findings provided a better understanding of the research on the anti-carcinogenic effects of TVA and this may facilitate the manufacture of TVA/c9, t11-CLA fortified ruminant products.

【 授权许可】

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© 2014 by the authors; licensee MDPI, Basel, Switzerland.