Marine Drugs | |
Co-Cultivation—A Powerful Emerging Tool for Enhancing the Chemical Diversity of Microorganisms | |
Andreas Marmann1  Amal H. Aly1  Wenhan Lin3  Bingui Wang2  | |
[1]Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine University, Universitaetsstrasse 1, Bldg. 26.23, Duesseldorf 40225, Germany | |
[2] E-Mails: | |
[3]Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road 7, Qingdao 266071, China | |
[4] E-Mail: | |
[5]State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Health Science Center, Beijing 100191, China | |
[6] E-Mail: | |
关键词: marine-derived microorganisms; co-cultivation; mixed fermentation; silent genes; natural products; | |
DOI : 10.3390/md12021043 | |
来源: mdpi | |
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【 摘 要 】
Marine-derived bacteria and fungi are promising sources of novel bioactive compounds that are important for drug discovery programs. However, as encountered in terrestrial microorganisms there is a high rate of redundancy that results in the frequent re-discovery of known compounds. Apparently only a part of the biosynthetic genes that are harbored by fungi and bacteria are transcribed under routine laboratory conditions which involve cultivation of axenic microbial strains. Many biosynthetic genes remain silent and are not expressed
【 授权许可】
CC BY
© 2014 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
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