Casein Kinase 1 Epsilon Expression Predicts Poorer Prognosis in Low T-Stage Oral Cancer Patients

International Journal of Molecular Sciences

Shu-Hui Lin¹  Yueh-Min Lin²  Chung-Min Yeh²  Chih-Jung Chen¹  Mei-Wen Chen³  Hsiao-Fang Hung⁴  Kun-Tu Yeh² 

[1] Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan; E-Mail:;Department of Surgical Pathology, Changhua Christian Hospital, Changhua 500, Taiwan; E-Mails:;Tumor Center, Changhua Christian Hospital, Changhua 500, Taiwan; E-Mail:;Department of Medical Technology, Jen-Teh Junior College of Medicine, Nursing and Management, Miaoli 356, Taiwan; E-Mail:

关键词: casein kinase 1 epsilon (CK1ɛ);    oral cancer;    overall survival;   

DOI  :  10.3390/ijms15022876

来源: mdpi

【 摘 要 】

Casein kinase 1 is a group of ubiquitous serine/threonine kinases that are involved in normal cellular functions and several pathological conditions, such as DNA repair, cell cycle progression, cytokinesis, differentiation, and apoptosis. Recent studies have indicated that casein kinase 1-epsilon (CK1ɛ) and casein kinase 1-delta (CK1δ) expression has a role in human cancers. We investigated the associations between CK1ɛ and CK1δ expression and the clinical parameters of oral cancer using immunohistochemical study methods on oral squamous cell carcinoma specimens. The results of our immunohistochemical analysis showed that the loss of CK1ɛ expression was greatly associated with a poor four-year survival rate in oral cancer patients (p = 0.002). A Kaplan-Meier analysis showed that patients who had a loss of CK1ɛ expression had a considerably poorer overall survival rate than patients who had positive CK1ɛ expressions (p = 0.022). A univariate analysis revealed that patients who had a loss of CK1ɛ expression had considerably poorer overall survival (OS) than patients who had positive expression (p = 0.024, hazard ratio (HR) = 1.7). In conclusion, our data indicated that the loss of cytoplasmic CK1ɛ expression is greatly associated with poor survival and might be an adverse survival factor.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland