Mode of Action of Diterpene and Characterization of Related Metabolites from the Soft Coral, Xenia elongata

Marine Drugs

Eric H. Andrianasolo²  Liti Haramaty²  Eileen White¹  Richard Lutz² 

[1] The Cancer Institute of New Jersey, 195 Little Albany Street, New Brunswick, NJ 08903, USA; E-Mail:;Center for Marine Biotechnology, Institute of Marine and Coastal Sciences, Rutgers, The State University of New Jersey, New Brunswick, NJ 08901, USA; E-Mails:

关键词: structural and functional characterization of marine drug;    marine biotechnology;    bioactive compounds and bioproducts;    drug discovery and development;   

DOI  :  10.3390/md12021102

来源: mdpi

【 摘 要 】

Chemical and biological investigation of the cultured marine soft coral Xenia elongata led to the isolation of two new diterpenes (2, 3). Their structures were elucidated using a combination of NMR and mass spectrometry. Biological evaluations and assessments were determined using the specific apoptosis induction assay based on genetically engineered mammalian cell line D3 deficient in Bak and Bax and derived from a mouse epithelial cell. The diterpenes induce apoptosis in low micromolar concentrations. The results indicate that the previously isolated compound (1) affects cell in a manner similar to that of HSP90 and HDAC inhibitors and in a manner opposite of PI3 kinase/mTOR inhibitors. Compound (3) inhibits selectively HDAC6 in high micromolar concentrations.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.